BLUESENS GAS SENSOR GMBH - understanding bioprocesses

BlueVary is a maintenance free gas analyzer for variable biotechnological applications. By selectable sensor cartridges different measuring tasks ranging from microbial, cell culture to monitoring of algae and biogas processes can be covered by just one device. The analyzer consists of a basis element with measurement places for two of the variable sensor cartridges. The third place holds a cartridge to compensate pressure and/or humidity. The integrated display ensures an overview about sensor and concentrations at any time. As already known from the forerunner analyzers BlueVary can be mounted on each fermenter from lab to production scale by using different mechanical connections without being limited by fermenter brand or manufacturer. Various data outputs are available. Annual maintenance is not necessary. In combination with the open software BlueVis the BlueVary turns into a versatile, effective tool for real-time online monitoring and optimization of bioprocesses of any kind.

The robust BCP-CH4 methane sensor is based on infrared gas measurement techique and is available in 2 different wavelengths. Minimum flow is not needed and it can be integrated directly into the gas pipe. A gas cooling is no longer required. Monthly adjustment can be done with fresh air. The sensor is longterm stable and IP65 accredited. The production of methane in biogas plants (methane digester) can be monitored by the BCP-CH4 sensor which helps to optimize the process control. By using BCP-CH4 in block heat and power plants the actual efficiency can be determined.

Off gas analysis in bioprocesses delivers important informatione about respiratory activity like CTR from which actions for process optimization and scale-up can be deduced from. The BCP-CO2 sensor will help you to understand and control your processes better. The CO2 analyzer BCP-CO2 services for application in fermenters and bioreactors of any scale. No matter if you are working in big stainless steel tanks, shake flasks, disposable, single-use or parallel reactorsthe BCP-CO2 is easy to install, doesn´t need much maintenance and offers an integrated, automatic pressure and temperature compensation. BCP-CO2 measures directly in the process. Additional pipes are not necessary. The extremely robust sensor has a IP65 aluminium housing and is well applicable under harsh process conditions.

Oxygen is essential for life. Measuring oxygen concentrations plays a central role in controlling biotechnological processes . No matter if fermentations, scale-up studies, bioproductions in lab or industrial scale, the BCP-O2 sensor determines the oxygen concentration in realtime (real time monitoring) in a very convenient way. By measuring the oxygen concentrations oxygen limitations can be avoided and conclusions to metabolic activity can be drawn. With the help of measuring the oxygen important process parameters as OTR oxygen transfer rate or respiratory quotient RQ can be determined. Using BCP-O2 simplifies process optimization in bioprocessing and makes it efficient and precise. In contrast to other sensors the BCP-O2 has in integrated automated temperature and pressure compensation and can be connected to each and every fermenter type. BCP-O2 doesn´t need a minimum flow rate and thus can be applied from small (lab) scale (e.g shake flask) up to the large industrial scale.

The BCpreFerm is a whole gas analysis for scale-up processes. Made for the analysis of metabolic processes, the model is composed of up to 6 CO2- and O2-senors, a BACCom data multiplexer box, and the BlueVis-software for automatic data recording. Growth is controlled through a parallel analysis of CO2 and O2, a display of OTR, CTR and RQ, and through defined trial conditions. The system uses a modular design which enables connection to shake flasks, as well as to fermenters. It can also be attached to existing bioreactors. The use of additional gas coolers, lines, pumps and valves, and the complicated processing of gases is no longer necessary. The instrument can be used for cultivations in shake flasks and fermenters and further applications.

Automatic parallel online determination of (bio)methane potential is essential to ensure the effectivity of biogas production. Yieldmaster simplifies the search for the right substrae and guarantees maximums yields for your biogas process. Using Yieldmaster minimum gas flows are not necesseray. The Yieldmaster (BCS-CH4 biogas) consists of CH4 infrared gas sensors, precision volumeters and BAcVis or BlueVis software. It can be used from small vessels (500mL) up to big lab fermenters. Data is recorded consistently. Using date from the integrated temperature measurement BacVis or BlueVis calculate the standard volume automatically. Sensors measure directly in the fermenter which means no data is lost and errors caused by gas leakage etc. are minimized. The compensating reservoir device guarantees complete measurement under all circumstances. In combination with BlueVCount (Yieldmaster 2.0) simultaneous measurement of methane and gas volumes is feasable.

The analyzer for carbon dioxide and oxygen has been specially designed for monitoring cell growth processes in biotechnology. The device can be installed directly in the exhaust flow of the bioprocess and measures the concentration of CO2 and O2 there in real-time. The BlueInOne Cell automatically compensates any fluctuations of pressure and humidity in the system. The readings are therefore extremely accurate even under fluctuating measuring conditions. The BlueInOne Cell gas analyzer is fitted with an IR CO2 sensor, as well as a electrochemical oxygen sensor with galvanic cell. The O2 detector offers a measuring range of 0-100 % Vol. for oxygen, long-term stability and has a very high resolution of 50 ppm. The device can also analyze anaerobic processes with high precision.

BlueVis: Unified Bioprocess Management. With BlueVis software bioprocesses can be monitored and controlled in an easy way. Sensors and probes can be connected independently from brand. All data will be logged and visualized in real-time. BlueVis processes the data and automatically calculates key parameters (like OUR, CTR, RQ etc.) via integrated soft sensors. Actuators like pumps, stirrers, cryostates or thermostats can be operated and controlled to optimize the process. The software offers all data to process lead systems via integrated OPC server. This way BlueVis is open in both directions. BlueVis is fair and professional solution for all paramteres and applications in bioprocessing. BlueVis: one solution for all parameters and applications.

BlueInOne Ferm is an online gas analyzer for biotechnological processes. It features the parallel online estimation of CO2 and O2 combined in one compact, space saving sensor. The BlueInOne Ferm is pressure and humidity compensated and can be applied for fermenters of each size and brand. No matter if lab scale or production the BlueInOne Ferm analyzer works independent from flow, offers various mechanical connections and comprises various data output possibilities. BlueInOne Ferm is state-of-the-art. It´s PAT and QbD conform and stands for highest precision and reliability.

The BCP-H2 model is manufactured by Bluesens, and is a hydrogen analyzer that is easy to integrate directly into the gas lines. It has a cost effective and robust design, which has an in-situ gas analysis. The unit has a direct integration in gas pipes, and has installation of additional gas pipes is not necessary. It has a fast installation due to its standard connection with low maintenance costs. It can be utilized in wide variety of applications including chemical industry, biogas production and agriculture.