3d models - Import export

Using functional and standardised 2D or 3D living skin models, the bioassays performed by StratiCELL are very powerful tools for assessing the efficacy and mechanisms of action of products aimed at reducing skin inflammation and increasing skin barrier resilience. Examples of assays performed at StratiCELL: Barrier resilience and biomarkers NFkB translocation/activation Morphological alterations (such as spongiosis) Cytokines and chemokines release (IL1a, IL-1ß, IL-6, IL-8, etc.)

Psoriasis is a T cell-mediated inflammatory disease in which the Th17 and Th22 responses play a major role. StratiCELL has developed two models of 3D epidermis mimicking psoriatic features induced respectively by IL-17 and IL-22. Examples of assays performed at StratiCELL: Hyperplasia Parakeratosis Specific Biomarkers (DEFB4, S100A7, IL-19, …)

StratiCELL offers product objectivation studies on a wide range of skin models, including cell cultures in monolayer (keratinocytes, fibroblasts, melanocytes, adipocytes, sebocytes, sensory neurons, endothelial cells, etc.), human reconstituted epidermis and finally, human skin explants. All these 2D or 3D models can be derived from primary, hiPS-derived cells or from particular conditions (i.e. from psoriatic or AD patients), and can be stimulated or exposed to stress factors as required. Our skin models are manufactured in-house and are the results of more than 15 years of R&D innovations. Skin cells in monolayer cultures In vitro reconstituted human epidermis Ex vivo skin explants

StratiCELL has an innovative device to show the pigmenting effect of a product on the macroscopic appearance of pigmented skin reconstructed in vitro, comparable to a clinical trial. High definition pictures are taken during or at the end of treatments and the device generates an automatic calculation of the individual typology angle (ITA), the pigmentation index (PI), and the colorimetric contrast (ΔC) of the skin. StratiCELL can also performed melanin content quantification (Solvable®), melanin staining (Fontana Masson) and immunolabelling of key biomarkers (TYRP1, MART1, etc.).Because the skin pigmentation process is more complicated than a simple synthesis of melanin, each of our pigmented skin models (3D) perfectly reproduces the complex and dynamic environments of cell interactions encountered “in vivo”. Our models include: Light to dark skin models with the photo-type of your choice Age Spots skin models Asian skin models and other ethnicities