BOLZ PROCESS TECHNOLOGY GMBH

COMBER Pressofiltro® Series PF 100 - PF 10000 Pharmaceutical design COMBER Pressofiltro nutsche filters or filter dryers are versatile units designed for multipurpose production facilities. To meet the demanding requirements for filters used in the manufacture of pharmaceutical ingredients, the filters are designed to meet stringent cGMP and FDA guidelines. Special properties for the customer’s benefit: Excellent cleanability using CIP systems, simple validation Openable filter base provides for good access to the filter internals for cleaning and inspection Easily interchangeable filter plates, with flat, homogeneous filter surfaces for good cleanability and inspection Multilayer and/or conventional filter materials Good drying performance with special agitator design, large heat exchange areas Double mechanical seals, externally interchangeable, dry running contacting or non-contacting lift-off type seals as well as liquid lubricated seals

COMBER Pressofiltro® - Series PF 2000 - PF 16000 Chemical design Chemical design Pressofiltro® agitated Nutsche filters, suction filters or filter dryers are versatile units equally suited for monoproduction applications and for multipurpose production facilities. Special properties for the customer’s benefit: Available as closed units with manhole access or with an openable filter base Multilayer and/ or conventional filter materials Good emptying characteristics due to narrow agitator to wall/ bottom clearances and a unique agitator blade design Shaft seal with externally accessible stuffing box

COMBER Pressofiltro® Series PF 50 - PF 6000 Steam Sterilizable Design COMBER Pressofiltro steam sterilizable agitated Nutsche filter dryers are designed to maintain full sterility during the entire process, from inerting through slurry feeding and filtration, washing and drying to discharge of the dry product. CIP and SIP provide a very effective, safe and convenient form of sterilization, easy to automate and validate. Special properties for the customer’s benefit: With Cleaning-In-Place (CIP) and Sterilization-In-Place (SIP) systems designed for the automatic cleaning and disinfecting of the equipment Steam sterilizable filter dryer design assures steam reaches all parts of the filter dryer in contact with the product and air is not trapped in the unit during sterilization In compliance with cGMP and FDA guidelines, with vessel interior and all associated piping designed to prevent product adherence and to facilitate cleanability, fully drainable for clearance of condensate...

COMBER Pressofiltro® Series PF 50 - PF 2000 with Containment System Pressofiltro® agitated Nutsche filters or filter dryers with containment system provide protection of the operators against hazardous materials and equally provide product or process safety against possible contamination from external particles. Special properties for the customer’s benefit: Containment systems (glove boxes) are designed to allow contamination free sampling, product discharge, heel removal and product pack-off into suitable containers Containment systems are available as passive, active, single chamber, two chamber and multiple chamber designs, all in compliance with cGMP and FDA guidelines Active isolator units are equipped with air handling systems and HEPA inlet and exhaust filters for containment levels down to 10 ng/m³ TWA The isolator design permits sampling, product discharge, pack-off, heel removal and filter cloth disposal in a single unit Sample and small items transfer using optional...